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Mayo Finds Convalescent Plasma Safe

June 26, 2020

Mayo Finds Convalescent Plasma Safe

Mayo Clinic researchers and collaborators have found investigational convalescent plasma to be safe following transfusion in a diverse group of 20,000 patients.

   The findings from the U.S. Food and Drug Administration’s Expanded Access Program for COVID-19 are reported in Mayo Clinic Proceedings. The safety report assessed the 7 days following transfusion for hospitalized patients between April 3 and June 11 who were deemed at risk of progressing to a severe or life-threatening condition. Nearly 40% of the patients were women, 20% African Americans, nearly 35% Hispanic, and 5% Asian. Compared to 12% in a previous safety study, 7-day mortality rates declined to 8.6 % in the first 5,000 transfused patients. Serious adverse events continued to be less than 1%. This expanded safety report revealed a decline in mortality which appears contemporary with the more rapid availability of plasma for use, but the authors caution that this alone does not provide any evidence on effectiveness of convalescent plasma for treating COVID-19. Given the accelerating use of the therapy, research is now broadening its focus to determine indicators of efficacy.
   —Please see https://newsnetwork.mayoclinic.org/discussion/mayo-finds-convalescent-plasma-safe-for-diverse-patients-with-covid-19/ for more on this.