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Publication AbstractsThermal Regulation in the Heat During Exercise After Caffeine and Ephedrine IngestionBell DG, Jacobs I, McLellan TM, Miyazaki M, Sabiston CM AbstractBackground: Ingesting a combination of caffeine and ephedrine (C+E) has been shown to raise metabolic heat production and body temperature. This side effect of C+E ingestion may be positive during a cold stress scenario, however, during heat stress it could prove to be detrimental. Thus, the purpose of this study was to clarify the effect of C+E ingestion on body temperature regulation during moderate exercise in a hot dry environment. Methods: Ten, healthy, non heat acclimated, males exercised at 50% V(dot)O2peak in a 40°C and 30% RH environment until rectal temperature reached 39.3°C; heart rate (HR) remained at 95% of peak value or greater for 3 min, dizziness or nausea precluded further exercise, or 3 h had elapsed. They did this four times at weekly intervals: familiarization (Fam), control (Cont), placebo, and C+E (5 mg · kg-1 caffeine + 1 mg · kg-1 ephedrine) trials. The Fam and Cont treatments were done first and sequentially while the placebo and C+E treatments were balanced and double-blind. Tolerance times, mean skin temperature (T(macron)sk), rectal temperature (Tre), V(dot)O2, V(dot)CO2, V(dot)E, sweat rate (SR), HR, and sensation of thermal comfort were measured. Results: Tolerance times (mean ± SD in minutes) were similar for the placebo (120.0 ± 28.4) and C+E (121.3 ± 33.9) trials and both times were significantly longer than Cont (106.6 ± 24.0) trial. C+E did not affect T(macron)sk, initial Tre, Delta Tre, SR or the sensation of thermal comfort. V(dot)O2 and V(dot)E, were significantly increased by C+E. HR was elevated by C+E compared with the other trials, but only during the initial 20 min of exercise. Conclusion: Although the metabolic rate was slightly increased with C+E treatment, it was sufficiently offset by increased heat loss mechanisms so that internal body temperature was not increased during moderate exercise in a hot, dry environment.Keywords: ergogenic, methylxanthine, sympathomimetic, heat stress, metabolism. Information on subscribing, and on obtaining copies of an article or of an entire issue. Table of Contents for Volume 70, Number 6 of the ASME journal.
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