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Publication AbstractsEndocrine Status and LBNP-Induced Hormone Changes During a 438-Day Spaceflight: A Case StudyHinghofer-Szalkay HG, Noskov VB, Rössler A, Grigoriev AI, Kvetnansky R, Polyakow VVAviat Space Environ Med 1999; 70:1-5. AbstractWe investigated basal levels and lower body negative pressure (LBNP)-induced changes of volume regulating (PRA, aldosterone, AVP, ANP) and other stress-sensitive hormones (catecholamines, cortisol, ACTH) in venous plasma from one cosmonaut before (-45 d), during (3, 170, 287, 430 d) and after (+4, +90 d) a record-breaking long-term (438 d) spaceflight. Blood was taken at the beginning and immediately after ending LBNP (-15/-30/-35 mm Hg for 15/15/10 min, respectively) preflight supine, inflight, and postflight supine. PRA, aldosterone, and vasopressin levels stayed within normal boundaries during the entire flight and after landing. Catecholamines exceeded reference limits (epinephrine > 140 pg·ml-1, norepinephrine > 1000 pg·ml-1) 5 and 9 mo inflight, and 4 d postflight. ANP and cGMP were lower inflight (p < 0.04) than pre- or postflight. Cortisol and ACTH were not consistently altered. LBNP-induced hormonal changes were not different (p > 0.05) in microgravity and 1-G. Based on data from one cosmonaut, we conclude that long-term spaceflight up to 430 d duration appeared to lower plasma ANP and cGMP during flight and occasionally elevate catecholamine levels, without significantly altering LBNP-induced relative hormone changes as compared with those observed on the ground.Keywords: long-duration spaceflight, endocrine blood volume regulation, cardiovascular stress, atrial natriuretic, peptide, venin, aldosteron, vasopressin, catecholamines. Information on subscribing, and on obtaining copies of an article or of an entire issue. Table of Contents for Volume 70, Number 1 of the ASME journal.
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